Pulmonary alveolar echinococcosis (AE) caused by the metacestode of Echinococcus multilocularis is a lethal zoonosis and 14 is a lesion secondarily induced by hematogenous dissemination from hepatic AE lesions. H Nagahata, S Matsuki, H Higuchi, O Inanami, M Kuwabara, K Kobayashi. Masaki Nagane, Hironobu Yasui, Tohru Yamamori, Songji Zhao, Yuji Kuge, Nagara Tamaki, Hiromi Kameya, Hideo Nakamura, Hirotada Fujii, Osamu Inanami. After the C6/36 cells were incubated at 45 degreesC in order to induce apoptosis, the 46 kDa protein continued to be detected for at least 3 h. The internalization of fluorescein-labelled bacteria was inhibited by a JNK-specific inhibitor SP600125, suggesting that phagocytosis involves the JNK signalling pathway in mosquito cells. Background: A novel anticancer drug 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS106) has been shown to radiosensitize tumor cells and to improve the therapeutic efficiency of X-irradiation. They were treated with a relatively low dose of X-irradiation (2 Gy) and low amounts of TAS106 (0.1 mg/kg and 0.5 mg/kg). OGD/reoxygenation-induced cell death was evaluated by LDH release into the culture medium. Furthermore, extracellular pH mapping was used to visualize the spatial distribution of acidification in different tumor xenograft mouse models of human-derived pancreatic ductal adenocarcinoma cells. These findings demonstrate that bovine lactoferrin has anti-tumor activity in canine mammary tumors and has the potential for use in tumor-bearing dogs. M Kuwabara, Y Iida, O Inanami, S Sawamura, K Yokoyama, M Tsujitani. The expression of anti-apoptosis proteins, inhibitor of apoptosis protein (IAP) family members (survivin and XIAP) and BCL2 family members (Bcl-X(L) and Bcl-2), in purvalanol A-treated cells with and without X rays was significantly lower than for cells exposed to X rays alone. Western blotting showed that protein tyrosine kinase (PTK) and extracellular signal-regulated kinase (ERK) in feline PBMC were activated within 10 min after the ConA stimulation and that the activation of both kinases had almost disappeared by 40 min after stimulation. TPO plus interleukin 3 was the optimal combination for survival of both types of CFU-Meg after X irradiation. Kenichiro Maeda, Hironobu Yasui, Tohru Yamamori, Taeko Matsuura, Seishin Takao, Motofumi Suzuki, Akira Matsuda, Osamu Inanami, Hiroki Shirato.

The effect of 1-(3-C-ethyny1-beta-D-ribo-pentofuranosyl)cytosine (ECyd) on proton-induced cell death was evaluated in human lung carcinoma cell line A549 and Chinese hamster fibroblast cell line V79 to enhance relative biological effectiveness (RBE) within the spread-out Bragg peak (SOBP) of proton beams. Purpose: To examine how hypoxia influences ionizing irradition-induced apoptosis in cultured mammalian cells and how a hypoxic cell radiosensitizer sensitizes apoptosis under hypoxic conditions. Conclusion: These results revealed that chelation of calcium merely delayed the onset of the radiation-induced apoptosis regulated by the activation of SAPK/JNK and caspase-3, and calcium was not essential for the induction of apoptosis in X-irradiated MOLT-4 cells. The decomposition of glycididazole to metronidazole reduced its radiosensitizing efficiency in vivo.

When isolated mitochondria were incubated with NADH, succinate and CYPMPO, an ESR spectrum due to CYPMPO-OOH was detected.

Copyright © Oita FootBall Club Co.,Ltd. These results suggest the signaling pathway of actin polymerization mediated by PI3-K was different from that of p38 and ERK activation mediated by PI3-K. K Iwasaki, M Morimatsu, O Inanami, E Uchida, B Syuto, M Kuwabara, M Niiyama. This NADH/succinate-dependent O-2(-center dot) production from mitochondria of irradiated cells was significantly increased in comparison with that of unirradiated cells.

The present experiments were performed to examine whether treatment with TRAIL enhanced the cell killing in tumor cells exposed to ionizing radiation under hypoxia, since the presence of radioresistant cells in hypoxic regions of solid tumors is a serious problem in radiation therapy for tumors. The effect of genotoxic treatments with or without two novel MPS1 inhibitors, NMS-P715 and AZ3146, on cellular survival, cell-cycle distribution, centrosome status and mitotic catastrophe (MC) was evaluated. These results therefore suggest that the treatment of the cells with MP induced radiosensitization via the production of excess mitochondria-derived ROS in tumor cells. These findings, plus those from an earlier study (Inanami, O., Johnson, J, L., McAdara, J. K., El Benna, J., Faust, L. P., Newburger, P, E., and Babior, B, M. (1998) J. Biol. In this condition, malondialdehyde (MDA) and lactate dehydrogenase (LDH) were released into the supernatant.

These results suggest that the activation of p38 MAPK and the increase of [Ca2+](i) contribute separately to the H2O2-induced increase of EC permeability. Differentiation of bone marrow-derived cells toward thermogenic adipocytes in white adipose tissue induced by the β3 adrenergic stimulation. These findings demonstrate that bovine lactoferrin has anti-tumor activity in canine mammary tumors and has the potential for use in tumor-bearing dogs. The present study demonstrates that there are large individual differences in the radiosensitivity of hematopoietic progenitor cells as detected in steady-state human PB. The activation of PKC epsilon was observed after PBN stimulation.

K Niwa, O Inanami, T Yamamori, T Ohta, T Hamasu, T Karino, M Kuwabara. The spectral components are, respectively, denoted as immobile (lm), characterized by lower molecular mobility and higher ordering, and mobile (Mb) component of high mobility and low ordering.
Clinical trials have been carried out in human medicine based on these effects.

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